ABSTRACT
Infection is an important cause of morbidity and mortality in diabetic patients. Chronic hyperglycaemia impairs host defense mechanism such as cell mediated immunity, polymorphonuclear leukocyte (PMNL) function, antibody formation etc. PMNL serves as bodies first line of defense against various infections. The present study was undertaken to establish a correlation between impaired PMNL function, blood glucose levels and its improvement with good glycaemic control with glibenclamide and glimepiride, with special reference to parameters such as respiratory burst and O2(-) and H2O2 production by diabetic neutrophils.
Subject(s)
Adult , Aged , Blood Glucose/drug effects , Chronic Disease , Diabetes Complications/prevention & control , Diabetes Mellitus, Type 2/drug therapy , Female , Glyburide/therapeutic use , Glycated Hemoglobin , Humans , Hyperglycemia/prevention & control , Hypoglycemic Agents/therapeutic use , Immunity, Cellular , Male , Middle Aged , Neutrophils/physiology , Respiratory Burst , Sulfonylurea Compounds/therapeutic useABSTRACT
A study was conducted to establish the knowledge of correct dose calculations and conversion between mass concentration, dilution and percentage concentrations amongst medical and paramedical personnel handling patient, with life saving support system. A questionnaire was prepared having five standard questions to be answered in ten minutes by medical house officers and nurses. Results of the study suggested that the knowledge of correct dose calculations of both the medical and paramedical personnel needs to be improved to impart best possible management to the critically ill patients.
Subject(s)
Area Under Curve , Clinical Competence , Critical Care , Dose-Response Relationship, Drug , Humans , Medical Staff, Hospital/education , Nepal , Nursing Staff, Hospital/education , Pharmaceutical Preparations/administration & dosage , Surveys and QuestionnairesABSTRACT
A prospective assessment of the current status of prophylactic use of antimicrobial agents (AMAs) for caesarean section deliveries at BPKIHS, Dharan, Nepal was done. Data was collected by systemic random sampling of 349 in patient case sheets. The prevalence of use of ampicillin either alone or in combination with metronidazole was noted in both the elective and non-elective groups, either in the hospital or at discharge, while only 7.0-9.0% of patients receivedAMAs other than ampicillin. Ampicillin has been reported to be an effective AMA in reducing post-partum endometritis and our observation also corroborates with this finding.